Division of Basic Sciences,  National Cancer Institute,  National Institutes of Health
 

Harold Varmus, MD, Special Volunteer

varmus@mskcc.org
 

Varmus Lab Research at the NIH:

Our laboratory uses biochemical, genetic, and molecular approaches to understand the normal and oncogenic properties of several genes implicated in neoplasia.  Currently, our NCI lab has set up two model systems to study the genetic basis of lung carcinogenesis.  The first is a lung-specific retroviral gene delivery model based on expression of the avian retroviral receptor TVA in type-II airway epithelial cells (AEC-II). The second model system relies on doxycycline regulated target gene expression. We are using the doxycycline regulated system in AEC-II cells to examine the consequences of somatic mutations in K-ras and p53 for tumor initiation and maintenance.
 

Varmus Lab Staff:

Harold Varmus   Special Volunteer
Galen Fisher   Staff Scientist
Sheri Wellen   Biologist
 

Lab Address and information at the NIH:

 Varmus Lab
 DBS/NCI/NIH, Room 4A56
 49 Convent Drive
 Bethesda, MD  20892-4471

 Phone:    301-496-0541
 Fax:     301-496-0332

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