Signal Transduction Section
Recent Publications:
Mulholland N.M, Snyder S.K., Kolla S.S., and Smith, C.L.: Chromatin-dependent regulation of the MMTV promoter by cAMP signaling is mediated through distinct pathways. Exp Cell Res 287 361-73 2003
Keeton E.K., Fletcher T.M., Baumann C.T., Hager G.L.and Smith C.L.:Glucocorticoid receptor domain requirements for chromatin remodeling and trancriptional activation of the mouse mammary tumor virus promoter in different nucleoprotein contexts. J Biol Chem 277(22) 28247-55 2002
Soeth E., Thurber D.B., and Smith C.L.:The viral transactivator E1A regulates the mouse mammary tumor virus promoter in an isoform- and chromatin-specific manner. J Biol Chem 277(22) 19847-54 2002
Sheldon L.A., Becker M. and Smith C.L.:Steroid hormone receptor-mediated histone deacetylation and transcripiton at the mouse mammary tumor virus promoter. J Biol Chem 276(35) 32423-6 2001
Giannoukos G., Szapary D., Smith C.L., Meeker J.E. and Simons S.S. Jr.:New antiprogestins with partial agonist activity: potential selective progesterone receptor modulators (SPRMs) and probes for receptor- and coregulator-induced changes in progesterone receptor induction properties. Mol Endocrinol 15(2)
255-70 2001
List H.J., Smith C.L., Martinez E., Harris V.K., Danielsen M., and Riegel A.T.:Effects of antiandrogens on chromatin remodeling and transcription of the integrated mouse mammary tumor virus promoter Exp Cell Res 260(1) 160-5 2001
Smith C.L., Wolford R.G., O'Neill T.B., Hager G.L.:Characterization of transiently and constitutively expressed progesterone receptors: evidence for two functional states. Mol Endocrinol 14(7) 956-71
2000
Sheldon L.A., Smith C.L., Bodwell J.E., Munck A, Hager G.L.: A ligand binding domain mutation in the mouse GR functionally links chromatin remodeling and transcription initiation. Mol.Cell Biol 19 8146-8157 1999
List H.J., Smith C.L., Rodriguez O., Danielsen M., and Riegel A.T.:Inhibition of Histone Deacetylation Augments Dihydrotestosterone Induction of Androgen Receptor Levels: an Explanation for Trichostatin A Effects on Androgen-Induced Chromatin Remodeling and Transcription of the Mouse Mammary Tumor Virus Promoter Exp. Cell Res 252 471-478 1999
Lim C.S., Baumann C.T., Htun H., Xian W., Irie M., Smith C.L., and Hager G.L.: Differential localization and activity of the A and B forms of the human progesterone receptor using green fluorescent protein chimeras. Mol Endocrinol 13(3) 366-375 1999
Smith C.L. and Hager G.L.
Transcriptional Regulation of Mammalian Genes in vivo: A Tale of Two Templates
J Biol Chem 272(44) 27493-27497 1997
Smith C.L., Htun H., Wolford R.G., and Hager G.L.:
Differential activity of progesterone and glucocorticoid receptors on MMTV templates
differing in chromatin structure
J Biol Chem 272(22)14227-14235 1997
Pennie W., Hager G.L., and Smith C.L.: Nucleoprotein structure influences the response of the mouse mammary tumor virus promoter to activation of the cyclic AMP signalling pathway. Mol Cell Biol 15:2125-2134 1995
Nobukuni Y., Smith C.L.,Hager G.L. and Detera-Wadleigh S.D.: Characterization of the human glucocorticoid receptor promoter. Biochemistry 34:8207-8214 1995
Barsony J., Renyi I., McKoy W., Kang H.C., Haugland R.P., and Smith C.L.: Development of a biologically active fluorescent-labeled calcitriol and its use to study hormone binding to the vitamin D receptor Anal Biochem 229:68-79 1995
Smith C.L., Archer T.K., Hamlin-Green G. and Hager G.L.: Newly-expressed progesterone receptor cannot activate stable, replicated MMTV templates but acquires transactivation potential upon continuous expression. Proc. Nat. Acad. Sci. USA. 90:11202-11206 1993
Hager G.L., Archer T.K., Bresnick E.H., Fragoso G., John S. and Smith C.L.: The influence of chromatin structure on the binding of transcription factors to DNA. In: DNA and Chromosomes. Cold Spring Harbor Symp. Quant. Biol. 58:63-71 1993
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