Division of Basic Sciences,
National Cancer Institute,
National Institutes of Health

Modeling of the Effect of the Removal of Linker Histone from Chromatin Fibers

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A. A Computer-generated Model of a Linker Histone-depleted Chromatin Fiber.	B. Simulated SFM Image of the Fiber in "A"	C. Experimental SFM Image of Glutaraldehyde-fixed, H1/H5-depleted Chromatin Fiber
Simulated and Experimental SFM Images of Linker Histone-depleted Chromatin Fibers.

Linker histones appear to play a role in the three-dimensional structure of the fiber by helping maintain the DNA entry/exit angle.

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