National Cancer Institute Laboratory of Receptor Biology and Gene Expression National Institutes of Health

NCI Core Fluorescence
Imaging Facility

Fluorescence Multichannel Imaging and FISH Microscopy

This application runs on a Leica DMRA fluorescence wide-field upright microscope controlled by Metamorph software installed on a Windows 2000-based PC. This system is suitable for multi-channel imaging, for instance, multi-color FISH, as well as 3D and 4D imaging. A mercury lamp and appropriate filters are available for imaging of FITC(and GFP), YFP, CFP, DAPI, Cy3 (and rhodamine), Cy3.5 (and Texas Red),Cy5, Cy5.5 and Cy7. Data are acquired with a Photometrics SenSys 12 bit digital camera. The software enables creation of composite images with adjusted brightness and contrast. Images can be saved as TIFF files for import into other programs.

Instrument instructions in pdf format.