National Cancer InstituteLaboratory of Receptor Biology and Gene ExpressionNational Institutes of Health

Hormone Action and Oncogenesis Section

Bimodal Model for Activation by GR
from Chromatin Templates

Overview
Structure of
MMTV Chromatin
Gene Targetting
In Living Cells
Higher Order
Chromatin Transitions
Bimodal Model
for Gene Regulation
Receptors and Coactivators
Chromatin Remodeling
In-vitro
Molecular Basis
of Chromatin Remodeling
Ligand-dependent
Sub-nuclear Trafficking
Cytoplasmic/Nuclear Trafficking
in Living Cells
Negative Regulation
by Glucocorticoid Receptor
Selected Publications
Open Positions

Promoter in the context of
replicated chromatin is:

Richard-Foy & Hager - EMBO.J. 6:2321
Archer, Lefebvre, Wolford, & Hager - Science 255:1573

a) highly organized
b) repressed

Constitutive Factors Excluded from Array