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Related information:
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Brinkmann, U., Vasmatzis, G.,
Lee, B., Yerushalmi, N., Essand, M. and I. Pastan: PAGE-1, an X-linked
GAGE like gene that is expressed in normal and neoplastic prostate, testis,
and uterus., (submitted). Additional
information.
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Almog, O., Benhar, I., Vasmatzis,
G., Tordova, M., Lee, B., and I. Pastan: The
crystal structure of the disulfide-stabilized Fv fragment of anticancer
antibody B1: Conformational influence of an engineered disulfide bond.,
Proteins: Structure, Genetics and Function 31: 128-138, 1998.
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Vasmatzis, G., Essand, M., Brinkmann,
U., Lee, B., and I. Pastan: Discovery
of three genes specifically expressed in human prostate by expressed sequence
tag database analysis., Proc. Natl. Acad. Sci. USA 95: 300-304,
1998. Additional information.
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Wang, Y., Huq, H.I., de la Cruz,
X., and Lee, B.: A
new procedure for constructing peptides into a given C-alpha chain.
Fold. & Des. 3: 1-10, 1998.
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Lee, B. and Vasmatzis, G.: Stabilization
of protein structures. Current Opinion in Biotechnology 8: 423-428,
1997.
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de la Cruz, X., Mahoney, M., and
Lee, B.: Discrete
representation of the protein C-alpha chain. Fold. & Des. 2:
223-234, 1997.
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Brinkmann, U., Di Carlo, A., Vasmatzis,
G., Kurochkina, N., Beers, R., Lee, B., and Pastan, I.: Stabilization
of a recombinant Fv fragment by base-loop interconnection and VH-VL permutation.
J. Mol. Biol. 268: 107-117, 1997.
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Kocher, J.-P., Prevost, M., Wodak,
S. J., and Lee, B.: Properties
of the protein matrix revealed by the free energy of cavity formation.
Structure 4: 1517-29, 1996.
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Reiter, Y., Brinkmann, U., Lee,
B., and Pastan, I.: Engineering antibody Fv fragments for cancer detection
and therapy: Disulfide-stabilized Fv fragments. Nature Biotechnology
14: 1239-45, 1996.
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Lee, B., and Graziano, G.: A two-state
model of hydrophobic hydration that produces compensating enthalpy and
entropy changes. J. Am. Chem. Soc. 118: 5163-5168, 1996.
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de la Cruz, X. and Lee, B.: The
structural homology between uteroglobin and the pore-forming domain of
colicin A suggests a possible mechanism of action for UG. Protein
Science 5: 857-61, 1996.
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Lee, B., Kurochkina, N., and Kang,
H. S.: Protein
folding by a biased Monte Carlo procedure in the dihedral angle space.
FASEB Journal 10: 119-125, 1996.
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Reiter, Y., Brinkmann, U., Jung,
S.-H., Pastan, I., and Lee, B.: Disulfide-stabilization
of antibody Fv: Computer predictions and experimental evaluation. Protein
Eng. 8: 437-42, 1995.
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Lee, B.: New
approaches for analyzing solvent reorganization and hydrophobicity.
Methods in Enzymology, Vol. 259, Chapter 25, pp. 555-576, 1995.
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Kurochkina, N., and Lee, B.: Hydrophobic
potential by pair-wise surface area sum. Protein Eng. 8: 437-442,
1995.
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Reiter, Y., Kurucz, I., Brinkmann,
U., Jung, S.-H., Lee, B., Segal, D.M., and Pastan, I.: Construction
of a functional disulfide stabilized TCR Fv indicates that antibody and
TCR Fv frameworks are very similar in structure. Immunity 2:281-287,1995.
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Benhar, I., Padlan, E.A., Jung,
S.-H., Lee, B., and Pastan, I.: Rapid
humanization of the Fv of monoclonal antibody B3 by using framework exchange
of the recombinant immunotoxin B3(Fv)-PE38. Proc. Natl. Acad. Sci.
USA 91: 12051-12055, 1994.
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Kurochkina, N.A., Kang, H.S.,
and Lee, B.: Experiences with dihedral angle space Monte Carlo search for
small protein structures. Statistical Mechanics, Protein Structure,
and Protein Substrate Interactions, Doniach, S. ed., Plenum, New York,
NY, pp. 147-157, 1994.
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Roscoe, D.M., Jung, S.-H., Benhar,
I., Pai, L. Lee, B., and Pastan, I.: Primate
antibody response to immunotoxin: serological and computer-aided analysis
of epitopes on a truncated form of Pseudomonas exotoxin. Infect.
Immun. 62: 5055-5065, 1994.
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Sergeev, Y. and Lee, B.: Alignment
of beta-barrels in (a/b)8 proteins using hydrogen-bonding pattern.
J. Mol. Biol. 244: 168-182, 1994.
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Kreitman, R.J., Puri, R.K., Leland,
P., Lee, B., and Pastan, I.: Site-specific
conjugation to interleukin 4 containing mutated cysteine residues produces
interleukin 4-toxin conjugates with improved binding and activity.
Biochemistry 33: 11637-11644, 1994.
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Madan, B., and Lee, B.: Role
of hydrogen bonds in hydrophobicity: the free energy of cavity formation
in water models with and without the hydrogen bonds. Biophysical
Chem. 51: 279- 289, 1994.
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Lee, B.: Enthalpy-entropy
compensation in the thermodynamics of hydrophobicity. Biophysical
Chem. 51: 271-278, 1994.
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Lee, B.: Relation
between volume correction and the standard state. Biophysical Chem.
51: 263-269, 1994.
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Reiter, Y., Brinkmann, U., Jung,
S.-H., Lee, B., Kasprzyk, P.G., King, C.R., and Pastan, I.: Improved
binding and anti-tumor activity of a recombinant anti-erbB2 immunotoxin
by disulfide-stabilization of the Fv fragment. J. Biol. Chem. 269:
18327-18331, 1994.
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Reiter, Y., Brinkmann, U., Kreitman,
R.J., Jung, S.-H., Lee, B., and Pastan, I.: Stabilization
of the Fv fragments in recombinant immunotoxins by disulfide bonds engineered
into conserved framework regions. Biochemistry 33: 5451-5459,
1994.
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Reiter, Y., Brinkmann, U., Webber,
K.O., Jung, S.-H., Lee, B., and Pastan, I.: Engineering
disulfide bonds into conserved framework regions of Fv fragments: improved
biochemical characteristics of recombinant immunotoxins containing disulfide-stabilized
Fv. Protein Engineering 7: 697-704, 1994.
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Jung, S.-H., Pastan, I., and Lee,
B.: Design
of interchain disulfide bonds in the framework region of the Fv fragment
of the monoclonal antibody B3. Proteins: Structure, Genetics and
Function 19: 35-47, 1994.
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Brinkmann, U., Reiter, Y., Lee,
B., Jung, S.-H., and Pastan, I.: A
recombinant immunotoxin containing a disulfide-stabilized Fv fragment (dsFv)
and a truncated form of Pseudomonas exotoxin. Proc. Natl. Acad.
Sci. USA. 90: 7538-7542, 1993.
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McPhie, P., Parkison, C. Lee,
B., and Cheng, S.-Y.: Structure
of the hormone binding domain of human b1 thyroid hormone nuclear receptor:
Is it an a/b barrel? Biochemistry 32: 7460-7465, 1993.
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Suh, E., Lee, B., Narahari, B.,
Choudhary, A.N., and Martino, R.: Parallel computation of solvent accessible
surface area of protein molecules. Proceeding of the Seventh International
Parallel Processing Symposium, pp. 685-689, 1993.
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Brinkmann, U., Lee, B., and Pastan,
I.: Cytotoxicity
of recombinant immunotoxins containing the VH or VL domain of monoclonal
antibody B3 fused to Pseudomonas exotoxin. J. Immunol. 150:
2774-2782, 1993.
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Lee, B.: Estimation
of the maximum change in stability of globular proteins upon mutation of
a hydrophobic residue to another of smaller size. Protein Science,
2: 733-738, 1993.
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Juretic, D., Lee, B., Trinajstic,
N., and Williams, R.W.: Conformational
preference functions for predicting helices in membrane proteins. Biopolymers,
33: 255-273, 1993.
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Kang, H.S., Kurochkina, N.A.,
and Lee, B.: Estimation
and use of protein backbone angle probabilities. J. Mol. Biol. 229:
448-460, 1993.Additional information.
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Pastan, I., Lee, B., Jung, S.-H.,
and Brinkmann, U.: Recombinant disulfide-stabilized polypeptide fragments
having binding specificity. Patent application filed on June 14, 1993.
Application serial number: 08/077,252.
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Research Information
Laboratory of Molecular Biology
National Cancer Institute
National Institutes of Health
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