Our laboratory developed the first transgenic model model for prostate cancer which was driven by the expression of large and small T-antigen (Tag) from the C3(1) component of the rat prostatein 5' flanking region. Interestingly, female transgenic mice carrying the same transgene develop mammary cancer which exhibits many important features as observed in human breast cancer.

     

    Mammary Model

    • Overview: the C3(1)/SV40 T-antigen transgenic mouse model of mammary cancer: ductal epithelial cell targeting with multistage progression to carcinoma.
    • Oncogene (Review), 2000: The mammary pathology of genetically engineered mice: the consensus report and recommendations from the Annapolis meeting.
    • Cancer Research, 2000: Estrogen Promotes Mammary Tumor Development in C3(1)/SV40 Large T-Antigen Transgenic Mice: Paradoxical Loss of Estrogen Receptora Expression during Tumor Progression.
    • The Original Paper-PNAS, 1994, Prostate and mammary adenocarcinoma in transgenic mice carrying a rat C3(1) simian virus 40 tumor antigen.
    • Histopathology (HistoBank-The Interactive Histology Atlas)
    • Biology of the Mammary Gland Web Page
    • Jax Labs
    • MMHCC Phenotype Database
    • Other related publications

    Prostate Model

    • Carcinogenesis, 1998: Altered expression of transforming growth factor betas during urethral and bulbourethral gland tumor progression.
    • Cancer Research, 1996: Progression of prostatic intraepithelial neoplasia to invasive carcinoma in C3(1)/SV40 large T antigen transgenic mice: histopathological and molecular biological alterations. .
    • The Original Paper-PNAS, 1994: Prostate and mammary adenocarcinoma in transgenic mice carrying a rat C3(1) simian virus 40 tumor antigen.

    Heterotopic Bone

    • Oncogene, 1999

    Salivary Gland

    • Oncogene, 1999